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ПРОБЛЕМА ПРОМЕЖУТОЧНОГО СИНДРОМА ПРИ ОТРАВЛЕНИЯХ АНТИХОЛИНЭСТЕРАЗНЫМИ СОЕДИНЕНИЯМИ

https://doi.org/10.36946/0869-7922-2017-4-40-49

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Аннотация

В обзоре рассмотрены современные представления об этиологии и патогенезе промежуточного синдрома при отравлениях антихолинэстеразными соединениями (фосфорорганические соединения, карбаматы). Представлена характеристика клинической картины синдрома и методов его диагностики с использованием электромиографии. Проанализированы и обобщены данные об опыте применения широко используемых базисных средств антидотной (реактиваторы холинэстеразы, M- и N-холинолитики) и патогенетической терапии отравлений. Для решения проблемы в качестве приоритетных направлений исследований определены поиск механизмов формирования недеполяризационного нервно-мышечного блока и разработка способов профилактики и лечения с использованием препаратов, воздействующих на N-холинорецепторы.

Об авторах

М. А. Тюнин
ФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации
Россия


С. В. Чепур
ФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации
Россия


А. С. Гоголевский
ФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации
Россия


Д. В. Селиванов
ФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации
Россия


Н. И. Бурцева
ФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации
Россия


Н. С. Ильинский
ФГБУ «Государственный научноисследовательский испытательный институт военной медицины» Министерства обороны Российской Федерации
Россия


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Для цитирования:


Тюнин М.А., Чепур С.В., Гоголевский А.С., Селиванов Д.В., Бурцева Н.И., Ильинский Н.С. ПРОБЛЕМА ПРОМЕЖУТОЧНОГО СИНДРОМА ПРИ ОТРАВЛЕНИЯХ АНТИХОЛИНЭСТЕРАЗНЫМИ СОЕДИНЕНИЯМИ. Токсикологический вестник. 2017;(4):40-49. https://doi.org/10.36946/0869-7922-2017-4-40-49

For citation:


Tyunin M.A., Chepur S.V., Gogolevsky A.S., Selivanov D.V., Burtseva N.I., Ilyinskiy N.S. THE PROBLEM OF THE INTERMEDIATE SYNDROME FOLLOWING POISONING WITH ANTI-CHOLINESTERASE AGENTS. Toxicological Review. 2017;(4):40-49. (In Russ.) https://doi.org/10.36946/0869-7922-2017-4-40-49

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ISSN 0869-7922 (Print)