The effect of a new technical product of the chloroacetamide class on the reproductive function of warm-blooded animals

Introduction. Pesticides recommended for use in agriculture must undergo a comprehensive toxicological and hygienic study, which is the basis for preventing their adverse effects on human and animal health, as well as on the sanitary state of the environment.

The purpose of the research is to study the effect of a new technical product of the chloroacetamide class on the reproductive function of laboratory animals (rats), to establish an inactive dose and hazard class.

Material and methods. Studies on the effects of a new technical product of the chloroacetamide class (TPC) were conducted in the vivarium of the F.F. Erisman Federal Scientific Center of Hygiene on the reproductive function of warm-blooded animals (rats, males and females). Previously, studies in this volume have not been conducted.

Results. In the study of reproductive toxicity, it was revealed that the no observed effect level (NOEL) of a new TPC for the parent generation and their offspring was set at the level of – 1/27 of LD₅₀.

Limitations. Related to the analysis of the results of experimental data on the study of the reproductive toxicity of the pesticide without taking into account the effects of embryotoxic and teratogenic effects on the body of warm-blooded (rats) as a result of exposure to a new technical product of the chloroacetamide class.

Conclusion. According to the “Hygienic classification of pesticides and agrochemicals according to the hazard class” (Methodological recommendations No. 1.2.0235–211 of 02/15/2021) on reproductive toxicity to the body of warm-blooded (rats), the new TPC refers to low-hazard compounds (hazard class 4).

Compliance with ethical standards. Compliance with ethical standards: The study was approved by the commission of the Ethics Committee of the F.F. Erisman Federal Scientific Center of Hygiene (protocol No. 11 dated 12.10.2021).

Funding. The study had no sponsorship.

Conflict of interest. The author declares no conflict of interest.

Accepted: February 9, 2024 / Revised: February 15, 2024 / Accepted: February 25, 2025 / Published: April 30, 2025

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