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Application of metabolomics methods as an occupational risk assessment tool (literature review)

https://doi.org/10.47470/0869-7922-2025-33-5-337-346

EDN: wsenku

Abstract

The implementation of omix technologies in various fields of medicine has been accelerating in recent years and is extremely relevant for industrial medicine. The identification of biomarkers that identify predictors of pathology, as well as individual sensitivity to harmful working conditions, helps reduce occupational health risks.

The article analyzes 84 literary sources devoted to the problems of biomonitoring in the context of the application of methods of metabolomicsin the field of industrial medicine.

Based on the analysis of data from both foreign and domestic literary sources, including articles in research journals, monographs, and guidelines, data on the use of metabolomics methods in medicine have been collected and analyzed. The prospects of this direction are revealed. The existing advantages and limitations of metabolomicsin the field of occupational health are considered.

The use of metabolomics methods opens up broad prospects in the field of personalized medicine. Monitoring the metabolic parameters of workers engaged in harmful industries makes a significant contribution to ensuring the safety of work and makes it possible to identify premorbid conditions, thereby reducing the likelihood of complications during the course of the disease.

Authors’ contribution:
Orlova O.I. – collecting literary data, writing a test, editing;
Ukolov A.I., Radilov A.S. – editing.
All co-authors – approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interests. The author declare no conflict of interest.

Funding. The study had no sponsorship.

Received: August 14, 2025 / Revised: September 09, 2025 / Accepted: October 2, 2025 / Published: November 19, 2025

About the Authors

Olga I. Orlova
Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agensy of Russia
Russian Federation

Candidate of Chemical Sciences, Leading Researcher, Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia, Leningrad region, Kuzmolovsky settlement, 188663, Russian Federation

e-mail: orlova@yandex.ru 



Anton I. Ukolov
Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agensy of Russia; Federal State-Financed Institution Golikov Scientific Research Clinical Center of Toxicology
Russian Federation

Candidate of Chemical Sciences, Head of the Department of Toxicology, Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia, Leningrad region, Kuzmolovsky settlement, 188663, Russian Federation

e-mail: Ukolov.ai@gpech.ru



Andrei S. Radilov
Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agensy of Russia
Russian Federation

Doctor of Medical Sciences, Professor, Acting Director, Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia, 188663, Russian Federation, Leningrad region, Leningrad region, Kuzmolovsky settlement,188663, Russian Federation

e-mail: no-reply@subs.elpub.ru



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Review

For citations:


Orlova O.I., Ukolov A.I., Radilov A.S. Application of metabolomics methods as an occupational risk assessment tool (literature review). Toxicological Review. 2025;33(5):337-346. (In Russ.) https://doi.org/10.47470/0869-7922-2025-33-5-337-346. EDN: wsenku

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