MATERIALS ON SUBSTANTIATION OF HYGIENIC STANDARDS FOR N-PENTYL ETHER OF CHLOROFORMIC ACID IN THE AIR OF THE WORKING AREA AND IN THE ATMOSPHERE
https://doi.org/10.36946/0869-7922-2019-4-43-47
Abstract
Pentyl chloroformate refers to moderately toxic substances when administered in the stomach (DL50 for white mice 1000,0 ± 86,0 mg/kg), has a pronounced irritant effect on the skin and mucous membrane of the eyes, has no skin-resorptive and sensitizing effect, weakly accumulates in the body. It shows selective irritant effect on the respiratory system on inhalation. The irritant threshold for rats is 7,8 mg/m3, for humans - 2,3 mg/m3. Hygienic standards for pentyl chloroformate are recommended for approval: MAC in the air of the working area - 0,5 mg/m3 (vapors, hazard class 2, marked «requires special protection for the skin and eyes»); tentative safe exposure level in the atmospheric air of populated areas - 0,005 mg/m3.
About the Authors
M. V. Bidevkina
Scientific Research Disinfectology Institute
Russian Federation
Russian Federation
Bidevkina Marina Vasil’evna
117246, Moscow
M. I. Golubeva
Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
Russian Federation
Russian Federation
Golubeva Margarita Ivanovna
142450, Staraya Kupavna, Moscow region
G. P. Pankratova
Scientific Research Disinfectology Institute
Russian Federation
Russian Federation
Pankratova Galina Pavlovna
117246, MoscowA. V. Limantsev
Scientific Research Disinfectology Institute
Russian Federation
Russian Federation
Limantsev Anatoliy Vladimirovich
117246, Moscow
I. N. Razumnaya
Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
Russian Federation
Russian Federation
Razumnaja Irina Nikolaevna
142450, Staraya Kupavna, Moscow region
А. L. Karaev
Scientific Research Disinfectology Institute
Russian Federation
Russian Federation
Karaev Andrey Lvovich
117246, Moscow
T. N. Potapova
Scientific Research Disinfectology Institute
Russian Federation
Russian Federation
Potapova Tat’yana Nikolaevna
117246, Moscow
References
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Review
For citations:
Bidevkina M.V., Golubeva M.I., Pankratova G.P., Limantsev A.V., Razumnaya I.N., Karaev А.L., Potapova T.N. MATERIALS ON SUBSTANTIATION OF HYGIENIC STANDARDS FOR N-PENTYL ETHER OF CHLOROFORMIC ACID IN THE AIR OF THE WORKING AREA AND IN THE ATMOSPHERE. Toxicological Review. 2019;(4):43-47. (In Russ.) https://doi.org/10.36946/0869-7922-2019-4-43-47
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