Toxicological Review
Toksikologičeskij vestnik

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Glushkovskaya EFFECT OF CHEMICAL FACTORS AND LIGHT STRESS ON BLOOD PARAMETERS OF LABORATORY ANIMALS

Е. V. Pleshakova, M. V. Kanevskiy, S. I. Yulaeva, A. A. Galitskaya, S. А. Konnova, O. V. Semyachkina-

https://doi.org/10.36946/0869-7922-2016-3-22-27

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Abstract

Individual and combined effects of sodium nitrite and amine (p-toluidine) including additional light stress conditions on laboratory mice were investigated. It has been established that the physical impact (light stress) for 107 days causes a significant increase in serum alanine aminotransferase activity and decrease of gammaglutamyltransferase activity in laboratory mice. A slight increase in the studied parameters of protein metabolism (urea and creatinine) in mice exposed to light stress was observed. Under exposure additional to chemical stress (enteral injection of a combination of sodium nitrite and p-toluidine), the activity of the enzymes indicator in serum increases: alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. A decrease in the activity of gamma-glutamyl transferase under combined action of stress conditions of various nature compared to the control was found. The observed effects of stress factors on the enzyme activity of blood serum correlate with pathomorphological changes in the esophagus and stomach.

Keywords

нитриты, n-толуидин, стресс, сывороточные ферменты

About the Authors

Е. V. Pleshakova

N.G. Chernyshevsky Saratov State University
Russian Federation

M. V. Kanevskiy

N.G. Chernyshevsky Saratov State University
Russian Federation

S. I. Yulaeva

Ltd «Medical and Diagnostic Center» Avesta»
Russian Federation

A. A. Galitskaya

N.G. Chernyshevsky Saratov State University
Russian Federation

S. А. Konnova

N.G. Chernyshevsky Saratov State University
Russian Federation

O. V. Semyachkina-

N.G. Chernyshevsky Saratov State University
Russian Federation

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Review

For citations:

Pleshakova Е.V., Kanevskiy M.V., Yulaeva S.I., Galitskaya A.A., Konnova S.А., Semyachkina- O.V. Glushkovskaya EFFECT OF CHEMICAL FACTORS AND LIGHT STRESS ON BLOOD PARAMETERS OF LABORATORY ANIMALS. Toxicological Review. 2016;(3):22-27. (In Russ.) https://doi.org/10.36946/0869-7922-2016-3-22-27

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ISSN 0869-7922 (Print)