TOXICITY AND HAZARD OF PHTHALATES (Literature review)
https://doi.org/10.36946/0869-7922-2019-6-3-9
Abstract
The analysis of literature data on toxicity and hazard of phthalic acid derivatives is carried out. It is shown that phthalates are widely used in various industries as plasticizers. With a single intake, phthalates, as a rule, are lowtoxic and low-hazard substances. Repeated exposure to these compounds leads to their accumulation in the body, having a polytropic effect with damage to the liver, kidneys, lungs, as well as embryotoxic and gonadotoxic effect. It is shown that the studied phthalates are dangerous for workers exposed to aerosols in the air of industrial premises. Based on the results of the analysis and summary of the literature, the following main conclusions are made. For an objective assessment of the danger of phthalic acid derivatives it is necessary to study the toxic effect of these compounds in subacute and chronic experiments. Establishing a hazard class for phthalates based only on the study of acute toxicity can lead to wrong conclusions with negative consequences for the health and lives of staff and the public.
About the Authors
I. E. Shkaeva
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
188663, Saint Petersburg
Russian Federation
188663, Saint Petersburg
S. A. Solntseva
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
188663, Saint Petersburg
Russian Federation
188663, Saint Petersburg
O. S. Nikulina
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
188663, Saint Petersburg
Russian Federation
188663, Saint Petersburg
A. I. Nikolaev
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
188663, Saint Petersburg
Russian Federation
188663, Saint Petersburg
S. A. Dulov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
188663, Saint Petersburg
Russian Federation
188663, Saint Petersburg
A. V. Zemlyanoy
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
188663, Saint Petersburg
Russian Federation
188663, Saint Petersburg
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Review
For citations:
Shkaeva I.E., Solntseva S.A., Nikulina O.S., Nikolaev A.I., Dulov S.A., Zemlyanoy A.V. TOXICITY AND HAZARD OF PHTHALATES (Literature review). Toxicological Review. 2019;(6):3-9. (In Russ.) https://doi.org/10.36946/0869-7922-2019-6-3-9
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