ASSESSMENT OF THE TOXICITY AND HAZARD OF SODIUM LAURYL SULFATE AT DIFFERENT EXPOSURE ROUTES
https://doi.org/10.36946/0869-7922-2020-4-56-59
Abstract
Sodium lauryl sulfate is the most common surfactant used in the production of detergents, chloroprene rubber, plastics, artificial furs and in pharmaceutical industry. Sodium lauryl sulfate is a moderately hazardous substance when introduced into the stomach (DL50 for white mice and rats is in the range of 2086-2700 mg/kg), has a pronounced local irritant effect on the skin and mucous membranes of the eyes, has a skin-resorptive, sensitizing and pronounced cumulative effects. The threshold for acute inhalation action is set at 15,3 mg/m3 for changes in the function of the nervous system and irritating effects on the mucous membranes of the upper respiratory tract (an increase in the total number of cells in the nasal flushes).
Recommended for approval tentative safe exposure level of sodium lauryl sulfate in the air of the working area is 0.2+ mg/m3 (aerosol).
About the Authors
M. V. Bidevkina
Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
Russian Federation
Russian Federation
Bidevkina Marina Vasil’evna
117246, Moscow
M. I. Golubeva
Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
Russian Federation
Russian Federation
Golubeva Margarita Ivanovna
142450, Staraya Kupavna
A. V. Limantsev
Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
Russian Federation
Russian Federation
Limantsev Anatoliy Vladimirovich
117246, Moscow
I. N. Razumnaya
Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
Russian Federation
Russian Federation
Razumnaya Irina Nikolaevna
142450, Staraya Kupavna
T. N. Potapova
Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
Russian Federation
Russian Federation
Potapova Tat’yana Nikolaevna
117246, Moscow
E. A. Fedorova
Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
Russian Federation
Russian Federation
Fedorova Emma Alexeevna
142450, Staraya Kupavna
References
1. OECD; SIDS Initial Assessment Report for SIAM 5. Sodium dodecyl sulphate (CAS No: 151-21-3). – 2005 – p. 17-20. Available at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1315 (accsessed 07 June, 2019)
Review
For citations:
Bidevkina M.V., Golubeva M.I., Limantsev A.V., Razumnaya I.N., Potapova T.N., Fedorova E.A. ASSESSMENT OF THE TOXICITY AND HAZARD OF SODIUM LAURYL SULFATE AT DIFFERENT EXPOSURE ROUTES. Toxicological Review. 2020;(4):56-59. (In Russ.) https://doi.org/10.36946/0869-7922-2020-4-56-59
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