MANIFESTATIONS OF SUBACUTE SYSTEMIC TOXICITY OF LEAD OXIDE NANOPARTICLES IN RATS AFTER AN INHALATION EXPOSURE
https://doi.org/10.36946/0869-7922-2020-6-3-13
Abstract
Outbred white female rats were exposed to an aerosol of lead oxide nanoparticles in a nose-only inhalation setup at an average concentration of 1.30 ± 0.10 mg / m3 during 5 days for 4 hours a day. In parallel, the control group of rats was subjected to sham exposure under similar conditions. The deposition of nanoparticles in the lungs and in the olfactory region of the brain was detected using transmission electron microscopy. Some disorders of the body state were detected in the exposed group, some of which can be considered as the result of a lead-specific toxic effect (an increase in the proportion of reticulocytes and in urinary excretion of δ-aminolevulinic acid), and others - the result of nanoparticles circumventing the blood-brain barrier (axon demyelination, vacuolization of the neurons’ cytoplasm).
About the Authors
M. Р. Sutunkova
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Sutunkova Marina Petrovna
620014, Yekaterinburg
S. N. Solovyeva
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Solovyeva Svetlana Nikolaevna
620014, Yekaterinburg
I. N. Chernyshov
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Chernyshov Ivan Nikolaevich
620014, Yekaterinburg
S. V. Klinova
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Klinova Svetlana Vladislavovna
620014, Yekaterinburg
V. B. Gurvich
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Gurvich Vladimir Borisovich
620014, Yekaterinburg
V. Ya. Shur
Institute of Natural Sciences, Ural Federal University
Russian Federation
Russian Federation
Shur Vladimir Yakovlevich
620000, Yekaterinburg
E. V. Shishkina
Institute of Natural Sciences, Ural Federal University
Russian Federation
Russian Federation
Shishkina Ekaterina Vladimirovna
620000, Yekaterinburg
I. V. Zubarev
Institute of Natural Sciences, Ural Federal University
Russian Federation
Russian Federation
Zubarev Ilya Vladimirovich
620000, Yekaterinburg
L. I Privalova
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Privalova Larisa Ivanovna
620014, Yekaterinburg
B. A. Katsnelson
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
Katsnelson Boris Alexandrovich
620014, Yekaterinburg
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Review
For citations:
Sutunkova M.Р., Solovyeva S.N., Chernyshov I.N., Klinova S.V., Gurvich V.B., Shur V.Ya., Shishkina E.V., Zubarev I.V., Privalova L.I., Katsnelson B.A. MANIFESTATIONS OF SUBACUTE SYSTEMIC TOXICITY OF LEAD OXIDE NANOPARTICLES IN RATS AFTER AN INHALATION EXPOSURE. Toxicological Review. 2020;(6):3-13. (In Russ.) https://doi.org/10.36946/0869-7922-2020-6-3-13
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