COMPARATIVE ASSESSMENT OF INVESTIGATIONS INTO TOXIC PROPERTIES OF NANOMATERIALS IN VIVO AND IN VITRO EXPERIMENTS
Abstract
The article presents results of studies on general toxic and irritant action of nanoscale particles of silver, zinc and titanium dioxide in experiments on animals and alternative models ( livestock sperm, Ecolum bacteria and vessels of chick embryo chorioallantoic membrane). Efficiency of using high sensitive alternative models is substantiated for screening assessment of general toxic and irritant action at the preliminary stage of general toxicological and irritant action investigations into nanoscale products .
About the Authors
Oksana Albertovna Guskova
State Budgetary Educational Institution of Higher Professional Education «Russian Medical Academy for Post-Graduate
Education»; Federal Budgetary Health Institution «hygienic and Epidemiological Center in the City of Moscow»
Russian Federation
Russian Federation
Nikolay Vsevolodovich Zavyalov
Federal Budgetary Health Institution «hygienic and Epidemiological Center in the City of Moscow»
Russian Federation
Russian Federation
Ekaterina Lvovna Skvorcova
Federal Budgetary Health Institution «hygienic and Epidemiological Center in the City of Moscow»
Russian Federation
Russian Federation
Khalidia Khizbulaevna Khamidulina
State Budgetary Educational Institution of Higher Professional Education «Russian Medical Academy for Post-Graduate
Education»; Federal Budgetary Health Institution «Russian Register of Potentially Hazardous Chemical and Biological
Substances», Rospotrebnadzor
Russian Federation
Russian Federation
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Review
For citations:
Guskova O.A., Zavyalov N.V., Skvorcova E.L., Khamidulina Kh.Kh. COMPARATIVE ASSESSMENT OF INVESTIGATIONS INTO TOXIC PROPERTIES OF NANOMATERIALS IN VIVO AND IN VITRO EXPERIMENTS. Toxicological Review. 2015;(1):22-28. (In Russ.)
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