CORRECTION BY TAUCIN OF LIVER METABOLIС AND FUNCTIONAL LIVER DISTURBANCES IN RATS INROXICATED WITH PARACETAMOL
Abstract
The combination of taurine (50 g/mole, 6.25g) with zinc diaspartate (1 g/mole, 0.35g) named «taucine-50», administrated in the rat stomach (0.50 g/kg over 10 days )increases the paracetamol-inhibited (administrated in the stomach 2.50 g/kg over 5 days) activity of succinate dehydrogenase, lactate dehydrogenase (LDH), nicotinamine adenine nucleotide – dehydrogenase (NADH) and acidic phosphatase (ACPH) in the rat liver and decreases in plasma an increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (AspAT) and alkaline phosphatase (ALP) as well as elevated content of total bilirubin, its conjugated forms and cholesterol. Hepatoprotective effect of «taucin-20» (0.5 g/kg/day) is less pronounced.
About the Authors
Anastasiya Urjevna Pashko
Education Institution "Grodno State Medical University" of Ministry of Health, Republic of Belarus: M.V. Korablev Pharmacology Department
Belarus
Belarus
Olga Alexandrovna Borisenok
Education Institution "Grodno State Medical University" of Ministry of Health, Republic of Belarus: M.V. Korablev Pharmacology Department
Belarus
Belarus
Mihail Ivanovich Bushma
Education Institution "Grodno State Medical University" of Ministry of Health, Republic of Belarus: M.V. Korablev Pharmacology Department
Belarus
Belarus
References
1. Katcung B.G. Basic and Clinical Pharmacology T. 1. Moskva: «Binom», Sankt- Peterburg: «Dialekt»; 2008 (in Russian).
2. Mashkovskij M.D. Drugs. Moskva: Novaja volna; 2005 (in Russian).
3. Acharya M. Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J. Biomed. Sci. 2010; 24: 31-3.
4. Pirs E. Histochemistry theoretical and applied. Moskva: «Inostrannaya litera-tura»; 1962. - 962 s (in Russian).
5. Rebrova O.Yu. Statistical analysis of medical data. Moskva: MediaSfera; 2002 (in Russian).
6. James L.P. [et al] Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drag Metab Dispos. 2009; 37:1779-84.
7. Sheybak V.M., Sheybak L.N. Biological role of a taurine in an organism of mammals. Meditsinskie novosti. 2005; 10: 65-15 (in Russian).
8. But-Gusaim L.St., Gerashchenko N.V., Bloshko T.E. Prospects of use of preparations of zinc in a perinatologi. Materialy nauchnoprakticheskoy konferentsii posvyashchennoy 60 let sluzhbe skoroy pomoshchi i 10 let UZ «GKO SMP». 5-7 sentyabrya 2005. Grodno: GrGMU; 2005 (in Russian).
Review
For citations:
Pashko A.U., Borisenok O.A., Bushma M.I. CORRECTION BY TAUCIN OF LIVER METABOLIС AND FUNCTIONAL LIVER DISTURBANCES IN RATS INROXICATED WITH PARACETAMOL. Toxicological Review. 2015;(1):42-45. (In Russ.)
Views:
142
Email this article 