INFLUENCE OF POTASSIUM BICHROMATE ON MORPHOLOGICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS
Abstract
The impact of Potassium Bichromate ( at 1 MAC dose) on morphological and immunological parameters of Wistar rats lymphoid organs was investigated in a chronic experiment (135 days). A lasting uptake of chromium by the Wistar rat organism induces a decrease of thymus mass and thymocytes number, causes a complex of structural and functional alterations evidencing about the status of accidental involution, lymphoreticular hyperplasia and plasmocytic and macrophage transformation of lymphoid nodes and spleen, induces a programmed death of thymocytes and lymphocytes in splenic T-zones and lymphoid nodes. Chromium induces morpho-functional changes in spleen shown by decrease in its weight and number of spelnocytes, lymphoid series cells and on the contrary by increase of erythroid series cells. The impact of chromium on the bone marrow was evident in a decreased level of myeloid series, neutrophils and on the contrary in increased amount of lymphoid cells and the content of erythroid cells as well.
About the Authors
Aleksandr Ivanovich Smolyagin
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Russian Federation
Russian Federation
Irina Valer’evna Mikhaylova
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Russian Federation
Russian Federation
Evgenija Vjacheslavovna Ermolina
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Russian Federation
Russian Federation
Aleksandr Abramovich Stadnikov
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Russian Federation
Russian Federation
Viktor Mihajlovich Boev
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Russian Federation
Russian Federation
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Review
For citations:
Smolyagin A.I., Mikhaylova I.V., Ermolina E.V., Stadnikov A.A., Boev V.M. INFLUENCE OF POTASSIUM BICHROMATE ON MORPHOLOGICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS. Toxicological Review. 2015;(2):40-44. (In Russ.)
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