CORRECTION WITH «TAUCINE» OF HEPATOTOXICITY PARAMETERS IN PLASMA OF RATS WITH CHOLESTASIS
Abstract
In rats with liver cholestatic injury ( common bile duct ligation during 13 days), a combination of taurine with zinc diaspartate in the ratio of 50 g/mole to 1 g/mole. («taucine-50») in dose of 0.5 g/kg shows a hepatoprotective effect judging from improvement of marker biochemical indicators of hepatotoxicity in plasma. As the period of cholesterase increases up to 21 days and hepatopathy is worsenig, «taucine-20» in the above mentioned dose also produces an equivalent hepatoprotective effect.
About the Authors
Anastasiya Urjevna Pashko
Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of the
Republic of Belarus
Belarus
Belarus
Kiryll Mikhailovich Bushma
Educational Institution «Grodno State Medical University»; Chair of Anaesthesiology and Intensive Care , Ministry of Health of the Republic of Belarus
Belarus
Belarus
Olga Alexandrovna Borisenok
Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of the
Republic of Belarus
Belarus
Belarus
Mihail Ivanovich Bushma
Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of the
Republic of Belarus
Belarus
Belarus
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Review
For citations:
Pashko A.U., Bushma K.M., Borisenok O.A., Bushma M.I. CORRECTION WITH «TAUCINE» OF HEPATOTOXICITY PARAMETERS IN PLASMA OF RATS WITH CHOLESTASIS. Toxicological Review. 2015;(3):12-15. (In Russ.)
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