THE STUDY OF ATROPINE EFFECT ON THE BLOOD ESTERASE STATUS IN RATS AT DIFFERENT WAYS OF UPTAKE OF MALATHION BY THE ORGANISM
Abstract
The therapeutic action of atropine (0.4, 2, 20 mg/kg) was assessed on models of rats intramuscular and intragastric poisoning with malathion in a dose of 1 LD50. It was demonstrated that the drug prevented animals death after the intramuscular administration of malathion and promoted the reduction of intensity of a cholinopositive symptomatology. It also promoted the recovery of the acetyl cholinesterase activity in rats blood up to 80% 8 hours after the therapy, and 24 hours after the injection of malathion, this index reached levels in the control group. The preparation had no protective effect on the modelled intragastric poisoning by malathion independently of its dose. In animals to which atropine (2mg/kg) was administrated an hour after intoxication, the enzyme activity in blood was 40% while in the control group it was 80%. It is practicable to take these findings into consideration while searching and selecting efficient medications for emergency treatment of organophosphorous intoxications.
About the Authors
Mikhail Anatol’evich Yudin
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense
Russian Federation
Russian Federation
Vladimir Nikolaevich Bykov
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense
Russian Federation
Russian Federation
Alexandr Maratovich Kolesnikov
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense
Russian Federation
Russian Federation
Andrey Mikhaylovic Sarana
City Hospital № 40
Russian Federation
Russian Federation
Il’ya Vladimirovich Yudnikov
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense
Russian Federation
Russian Federation
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Review
For citations:
Yudin M.A., Bykov V.N., Kolesnikov A.M., Sarana A.M., Yudnikov I.V. THE STUDY OF ATROPINE EFFECT ON THE BLOOD ESTERASE STATUS IN RATS AT DIFFERENT WAYS OF UPTAKE OF MALATHION BY THE ORGANISM. Toxicological Review. 2015;(3):16-20. (In Russ.)
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