STRATEGY AND TACTICS OF TNE PESTICIDE MUTAGENECITY ASSESSMENT
Abstract
Toxicological and hygienic risk assessment of pesticides widespread use to human health includes the analysis of their mutagenic activity as a compulsory part. A risk assessment strategy of pesticides mutagenic impacts based on their hygiene classification by mutagenicity criterion is presented. Changes in tactical approaches having occurred recently are considered. A set of methods harmonized with international requirements for assessment of mutagenic activity of pesticides, main metabolites and components of their preparative forms is recommended. It allows to determine a hazard class by a given harmful index. Issues are considered in respect to the usage of short-time testing for assessment of generic pesticides mutagenicity, determination of preparative forms potential genotoxicity and forecasting carcinogenic properties of substances under consideration.
About the Authors
Valery Nikolaevich Rakitskii
The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
Russian Federation
Russian Federation
Yulia Anatolevna Revazova
The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
Russian Federation
Russian Federation
Natalia Alexeevna Ilyushina
The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
Russian Federation
Russian Federation
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Review
For citations:
Rakitskii V.N., Revazova Yu.A., Ilyushina N.A. STRATEGY AND TACTICS OF TNE PESTICIDE MUTAGENECITY ASSESSMENT. Toxicological Review. 2015;(5):10-12. (In Russ.)
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