EXPERIMENTAL EVALUATION OF THE ELECTROMAGNETIC RADIATION PROTECTIVE ACTION AGAINST HYDRAZINE TOXICITY EFFECT
Abstract
It was found out that the exposure of rats to asymmetric dimethylhydrazine in a dose of 100 mg/kg leads to acute functional disorders of the central nervous system, toxic lesion of a number of vitally important organs during the two first hours. During the first 4 hours of intoxication, the survival of rats in control groups was 10% to 60%, a day after it did not exceed 20% and in some cases 100% lethality was already observed in the first hours of intoxication. The preventive exposure to electromagnetic radiation modulated by the preparation with the tissue of the brain pituitary-hypothalamic part in newborn infant rat (P1-4) over 4 days with a total exposition of 270 min. increased the rat resistance to the toxic action of asymmetric dimethylhydrazine. In that case the survival of rats over the first 4 hours of intoxication was of 80-90% and a day after lowered up to 40-70%. The corrective action of the given type of radiation with a total exposure time of 150 min. also increased the rat resistance to toxic effect of asymmetric dimethylhydrazine in the indicated dose. In that case the survival in the first 4 hours of intoxication was 80%-90% and 50%-80%. during the first days of intoxication.
About the Authors
Anna Aleksandrovna Kokaya
Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory
Russian Federation
Russian Federation
Vladimir Pavlovich Kozyakov
Research Institute of Occupational Pathology and Human Ecology of the Federal Medical-Biological Agency of Russia
Russian Federation
Russian Federation
Irina Vasyevna Mukhina
Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory
Russian Federation
Russian Federation
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Review
For citations:
Kokaya A.A., Kozyakov V.P., Mukhina I.V. EXPERIMENTAL EVALUATION OF THE ELECTROMAGNETIC RADIATION PROTECTIVE ACTION AGAINST HYDRAZINE TOXICITY EFFECT. Toxicological Review. 2014;(6):28-35. (In Russ.)
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