CONTENT OF METALLOTHIONEINS AND THE TOTAL PROTEIN IN SHEEP PERIPHERAL BLOOD LYMPHOCYTES UNDER CHRONIC DIETARY INTAKE OF LEAD NITRATE
Abstract
The content of the total protein and metallothioneins in peripheral blood lymphocytes of sheep which received lead nitrate with the diet in concentration of 5;25 and 150 mg/kg fodder was examined. Blood samples were taken from the sheep jugular vein before feeding on 7, 14, 28, 42, 70 and 90 days of investigation. The chronic intake of lead with the diet by the sheep organism is characterized by an increased level of metallothioneins in peripheral blood lymphocytes with simultaneous decrease of animals viability. At the same time, the amount of the total protein in the initial period of intoxication raises and in the subsequent periods decreases. Based on results obtained, it is suggested to use the determination of the metallothioneins content in peripheral blood lymphocytes as informative parameter to estimate mammalians exposure to lead.
About the Authors
Eldeniz Balabek ogly Mirzoev
State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
Vladimir Olegovich Kobyalko
State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
Irina Vladimirovna Polyakova
State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
Olga Aleksandrovna Gubina
State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
Natalya Aleksandrovna Frolova
State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
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Review
For citations:
Mirzoev E.B., Kobyalko V.O., Polyakova I.V., Gubina O.A., Frolova N.A. CONTENT OF METALLOTHIONEINS AND THE TOTAL PROTEIN IN SHEEP PERIPHERAL BLOOD LYMPHOCYTES UNDER CHRONIC DIETARY INTAKE OF LEAD NITRATE. Toxicological Review. 2014;(6):36-39. (In Russ.)
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