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BLOOD ESTRERASE PROFILE IN MICE AT ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2- BENZODIOXAPHOSPHORIN-2-OXIDE
https://doi.org/10.36946/0869-7922-2016-2-25-30
Abstract
The influence of 2-(o-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) on the blood esterase profile in mice was studied at different doses an hour and 24 h after its subcutaneous administration to animals. It is established that CBDP is not a specific carboxyl esterase inhibitor in mice blood serum as it equally inhibits blood butyrylcholinesterase as well. CBDP is a low effective acetylcholinesterase inhibitor in mice blood serum and does not pose an expressed effect in respect to acetylcholinesterase in erythrocytes membranes, however in high doses it is able to lower their amount.
About the Authors
D. S. Prokofieva
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
Russian Federation
V. I. Shmurak
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
Russian Federation
A. E. Krivoshein
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
Russian Federation
E. A. Bodryakova
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
Russian Federation
N. G. Voitenko
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Russian Federation
Russian Federation
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Review
For citations:
Prokofieva D.S., Shmurak V.I., Krivoshein A.E., Bodryakova E.A., Voitenko N.G. BLOOD ESTRERASE PROFILE IN MICE AT ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2- BENZODIOXAPHOSPHORIN-2-OXIDE. Toxicological Review. 2016;(2):25-30. (In Russ.) https://doi.org/10.36946/0869-7922-2016-2-25-30
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