Neurological aspects of modern drug addiction
https://doi.org/10.36946/0869-7922-2020-2-24-28
Abstract
The article presents the results of neurological examination of 95 patients with drug dependence. Neurological symptoms were evaluated comparatively in patients with non-injecting and injecting forms of dependence (n=17 and n=78, respectively). The obtained data of clinical neurological examination were compared with the indicators of magnetic resonance imaging of the brain and neurophysiological assessment of the state of peripheral nerves. A comprehensive analysis of the results of the study indicated that chronic intoxication with injecting drugs leads to the development of more pronounced and polymorphic neurological symptoms. It is also necessary to take into account the key role of intoxication in the formation of a cascade of reactions that change the functions of the nervous system.
About the Authors
B. S. Litvincev
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Litvincev Bogdan Sergeevich
192019, Saint Petersburg
D. P. Konstantinov
Saint Petersburg City Narcological Hospital
Russian Federation
Russian Federation
Konstantinov Dmitry Pavlovich
Saint Petersburg pan>
A. Yu. Efimcev
Almazov National Medical Research Centre, RF Ministry of Health
Russian Federation
Russian Federation
Efimcev Aleksandr Yurjevich
194156, Saint Petersburg
A. D. Petrov
Saint Petersburg City Narcological Hospital
Russian Federation
Russian Federation
Petrov Anton Dmitrievich
Saint Petersburg pan>
A. V. Fomichev
S.M. Kirov Military Medical Academy, RF Ministry of Defence
Russian Federation
Russian Federation
Fomichev Aleksej Vyacheslavovich
194044, Saint Petersburg
A. E. Sosyukin
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Sosyukin Anatolij Evgen’evich
192019, Saint Petersburg
E. V. Malysheva
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Malysheva Ekaterina Viktorovna
192019, Saint Petersburg
M. N. Vorob'eva
S.M. Kirov Military Medical Academy, RF Ministry of Defence
Russian Federation
Russian Federation
Vorob’eva Marina Nikolaevna
194044, Saint Petersburg
References
1. Golovko A.I., Ivanov M.B., Rejnyuk V.L., Ivnickij Yu.Yu., Barinov V.A., Dolgo-Saburov V.B. et al. World opioid crisis. Medline.ru. 2019; 20 (5): 44-53. Available at: http://medline.ru/public/art/tom20/art5.html (in Russian).
2. Hetea A. Cosconel C., Stanescu A.A.M., Simionescu A.A. Alcohol and psychoactive drugs in pregnancy. Maedica. 2019; 14 (4): 397-401.
3. Golovko A.I., Ivanov M.B., Golovko E.S., Barinov V.A. Information on synthetic cannabinoids that appeared in illicit trafficking in 2016-2017. Narcology. 2018; 17 (3): 71-78 (in Russian).
4. Golovko A.I., Barinov V.A., Bonitenko E.Yu., Zatsepin E.G., Ivanov M.B., Nosov A.V. et al. Toxicological characteristics of designer drugs. Medline.ru. 2015; 16 (4): 26-57. Available at: http//medline.ru/public/art/tom16/art4.html (Accessed 20 January 2015) (in Russian).
5. Stepanov I., Abrams J., Jain V., Walter K., Kittner D.L. Variation of toxic and carcinogenic constituents in nasvai: call for systematic research and regulation. Tobacco Control. 2017; 26 (3): 355-356.
6. Hua M., Sadah S., Hristidis V., Talbot P. Health effects associated with electronic cigarette use: automated mining of online forums. 2020; 22 (1). Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969389/.
7. Daras, M., Tuchman A.J., Marks S. Central nervous system infarction related to cocaine abuse. Stroke. 1991; 22 (10): 1320-1325.
8. Rubio M.A., Leon A., Moreira A., Navalpotro I., Muino E., Munteis E. et al. Acute atraumatic pluriradiculopathy after heroin consumption. Journal of Clinical Neuromuscular Disease. 2014; 15 (3): 87-88.
9. Kim Y., Kim J.W. Toxic Encephalopathy. Safety and health at work. 2012; 3 (4), 243-256.
10. Levin O.S. Ephedron encephalopathy. Korsakov Journal of Neurology and Psychiatry. 2005; 105 (7): 12-20 (in Russian).
11. Pylaeva O.A., Voronkova K.V. Addiction and epilepsy (literature review). Bulletin of epileptology. 2008; 2: 11-23 (in Russian).
12. Agibalova T.V., Poplevchenkov K.N. Cognitive impairment in patients with opioid addiction. Korsakov Journal of Neurology and Psychiatry. 2012; 5: 24-28 (in Russian).
13. Karkishchenko V.N., Karkishchenko N.N., Shustov E.B. Pharmacological basis of therapy. Moscow, Saint Peterburg, Ajsing; 2018 (in Russian).
14. Gofman A.G. Clinical narcology. Moscow: Medical Press Agency; 2017 (in Russian).
15. Aleksandrova T.V., Shilov V.V., Vasil'ev S.A., Aleksandrov M.V., Bortulev S.A., Mishin Yu.A. The state of cerebral blood flow in patients with severe poisoning with opioids of various groups. Bulletin of the Saint Petersburg State Medical Academy named after I. I. Mechnikov. 2011; 2: 1619 (in Russian).
Review
For citations:
Litvincev B.S., Konstantinov D.P., Efimcev A.Yu., Petrov A.D., Fomichev A.V., Sosyukin A.E., Malysheva E.V., Vorob'eva M.N. Neurological aspects of modern drug addiction. Toxicological Review. 2020;(2):25-29. (In Russ.) https://doi.org/10.36946/0869-7922-2020-2-24-28
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