EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS
https://doi.org/10.36946/0869-7922-2020-4-27-33
Abstract
Data on the biological activity of kappa-opioid receptor agonists - derivatives of three groups of compounds: 1,2-cyclohexylamine, 1,2,3,4-piperidine, 1,2,4-piperazine are presented. On the examples of 1,2-cyclohexylamine and 1,2,4-piperazine derivatives, it has been shown that a decrease in the length of the carbon chain in the phenylalkyl substituent at the nitrogen atom is accompanied by a decrease in the analgesic activity and toxicity of compounds. The replacement of chlorine atoms in the 3 and 4 positions of the phenyl ring with fluorine atoms, which are more electronegative, leads to an increase in the analgesic effect and a decrease in the toxicity of the compounds.
About the Authors
S. V. Chepur
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Chepur Sergei Viktorovich
195043, Saint Petersburg
S. E. Galan
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Galan Sergei Evgenievich
195043, Saint Petersburg
M. S. Vakhviayanen
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Vakhviayanen Maria Sergeevna
195043, Saint Petersburg
R. N. Khromov
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Khromov Roman Nikolaevich
195043, Saint Petersburg
A. N. Semenov
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Semenov Alexander Nikolaevich
195043, Saint Petersburg
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Review
For citations:
Chepur S.V., Galan S.E., Vakhviayanen M.S., Khromov R.N., Semenov A.N. EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS. Toxicological Review. 2020;(4):27-33. (In Russ.) https://doi.org/10.36946/0869-7922-2020-4-27-33
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