MALFORMATIONS OF CELLULAR COMPONENTS OF TOXEMIA AND THEIR CORRECTION AT ACUTE POISONINGS IN REHABILITATION PERIOD
Abstract
Observations on 59 patients suffering from a severe poisoning by various toxic agents, who were admitted to a rehabilitation toxicological department of N.V. Sklifosovsky Research Institute for Emergency Medicine were generalised. Those agents were psychopharmacological drugs (13), cauterizing liquids (18) and neurotoxicants (narcotics of opium group, ethanol, psychopharmacological (28). All the patients showed signs of endotoxemia of moderate severity: mean concentration of leukocytes in venous blood slightly exceeded normal limits and an increased concentration of dead cells in blood as well as of lymphocytes expressing Fas-surface receptor were noted. The obtained data were used to evaluate the effectiveness of non-drug therapeutic methods (laser hemotherapy, mesodiencephalic modulation, hyperbaric oxygen therapy) and pharmacotherapy (mexidol). Correction of endotoxemia using the above-mentioned methods in the complex therapy can significantly reduce the rehabilitation time in patients and may have a positive effect on the duration of hospital treatment.
About the Authors
Amayak Vazgenovich Badalyan
N.V. Sklifosovsky Research Institute of Emergency Medicine, Public Healthcare Institution of the Moscow Healthcare Department;State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Postgraduate Education», RF Ministry of Health
Russian Federation
Russian Federation
Natalya Valeryevna Borovkova
N.V. Sklifosovsky Research Institute of Emergency Medicine, Public Healthcare Institution of the Moscow Healthcare Department
Russian Federation
Russian Federation
Yuriy Semenovich Goldfarb
N.V. Sklifosovsky Research Institute of Emergency Medicine, Public Healthcare Institution of the Moscow Healthcare Department;State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Postgraduate Education», RF Ministry of Health
Russian Federation
Russian Federation
Yuliy Vadimovich Andreev
N.V. Sklifosovsky Research Institute of Emergency Medicine, Public Healthcare Institution of the Moscow Healthcare Department
Russian Federation
Russian Federation
Aleksandr Nikonorovich Elkov
N.V. Sklifosovsky Research Institute of Emergency Medicine, Public Healthcare Institution of the Moscow Healthcare Department
Russian Federation
Russian Federation
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Review
For citations:
Badalyan A.V., Borovkova N.V., Goldfarb Yu.S., Andreev Yu.V., Elkov A.N. MALFORMATIONS OF CELLULAR COMPONENTS OF TOXEMIA AND THEIR CORRECTION AT ACUTE POISONINGS IN REHABILITATION PERIOD. Toxicological Review. 2015;(6):2-9. (In Russ.)
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