CHEMICAL SAFETY AS TOXICOLOGICAL AND EPIDEMIOLOGICAL ISSUE IN MEDICAL SCIENCE AND PRACTICE
Abstract
The paper deals with factors of the current chemical burden of human population, including food and epidemiological disinfectants, and their potential toxicological impact. Methods of chemical exposure assessment in animal experiments are discussed on the basis of establishing thresholds of its severity. It was suggested that at the sub-threshold exposure, temporarily hidden health effects can also occur, which may only manifest in the form of relevant pathologies at population level. Not only individual but also collective (population) toxic exposure doses should be taken into account when evaluating chemical burden of human population; therefore it is reasonable to develop medical population toxicology as a special area within the toxicology science based both on epidemiological principles in general and on prognosticated advances in epidemiology of non-communicable diseases, in particular.
About the Authors
Viktor Aleksandrovich Tutelian
Federal State Budgetary Science Institution «Institute of Nutrition», Russian Academy of Sciences;State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov Moscow State Medical University»
Russian Federation
Russian Federation
Mikhail Georgiyevich Shandala
Federal Budgetary Science Institution «Institute of Discinfectology», Rospotrebnadzor;State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov Moscow State Medical University»
Russian Federation
Russian Federation
References
1. Onishchenko G.G. On sanitary and epidemiological environment. Gigiena i sanitariya, 2013; 2: 4-10 (in Russian).
2. State Standart 12.1.007-76. Harmful substances. Classification and General safety requirements, 1976 (in Russian).
3. Tutel’yan V.A., Monisov A.A., Khotimchenko S.A., Tereshkova L.P. Problems of food safety in Russia.Voprosy pitaniya. 1994; 3: 33-39 (in Russian).
4. Tutel’yan V.A. Food and Biosafety. Vestnik RAMN. 2002; 10: 14-19 (in Russian).
5. Shandala M.G. Topical issues of common Disinfectology. Selected lectures. M.: OAO «Izdatel’stvo Meditsina». 2009. 112 (in Russian).
6. Environmental health. G.I. Sidorenko, ed; AMN SSSR. M.: Meditsina. 1985. 304 (in Russian).
7. Comparative carcinogenic effectiveness of ionizing radiation and chemical compounds: Publication 96 NCRP: Filyushkina. M.: Energoatomizdat. 1992. 192 (in Russian).
8. The radiation. Doses, effects, risks. M.: Mir, R151988 - 79 (in Russian).
9. General toxicology. B.A. Kurlyandskiy, V.A. Filov, eds. M.: Meditsina. 2002. 608 (in Russian).
10. Zaytseva N.V., Shur P.Z., Kir’yanov D.A. Quantitative assessment of non-carcinogenic risk to human health. Gigiena i sanitariya. 2008. 6: 64-67 (in Russian).
11. Belyakov V.D., Yafaev R.Kh. Epidemiology: the textbook. M.: Meditsina. 1989. 416 (in Russian).
12. Bezel’ V.S., Bol’shakov V.N., Vorobeychik E.L. Population-based ecotoxicology. M.: Nauka. 1994. 80 (in Russian).
13. Il’in L.A., Kirillov V.F., Korenkov I.T. Radiation hygiene: the textbook. M.: Meditsina, 1999. 384 (in Russian).
14. Pokrovskiy V.I., Pak S.G., Briko N.I., Danilkin B.A. Infectious diseases and epidemiology: the textbook. M.: GOETAR MED. 2003. 816 (in Russian).
15. Radiation medicine. M.: publishing AT. 2002. T.3. 608 (in Russian).
16. Shandala M.G. The issues of selective toxicity in the security problem of disinfectant. Dezinfektsionnoe delo. 2013;1: 14-17 (in Russian).
17. Vlasov V.V. Epidemiology.Textbook. M.: GOETAR MED. 2004. 464 (in Russian).
18. Zaytseva N.V., Shur P.Z., Kir’yanov D.A. Methodical approaches to the assessment of population health risks based on evolutionary models. Zdorov’e naseleniya i sreda obitaniya. 2012; 1 (238): 4-6 (in Russian).
Review
For citations:
Tutelian V.A., Shandala M.G. CHEMICAL SAFETY AS TOXICOLOGICAL AND EPIDEMIOLOGICAL ISSUE IN MEDICAL SCIENCE AND PRACTICE. Toxicological Review. 2014;(6):2-7. (In Russ.)
Views:
187
Email this article 